Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | LPL | P06858 | 3/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA6 | P23280 | 1/20 | 0.30 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2298491 | 0.80 | ESR1 (0.40) | TSHR | |
| SCHEMBL7791563 | 0.80 | CA2 (0.38) | CA2ENPP2CA1LPLLIPG | |
| SCHEMBL4406045 | 0.77 | MAPT (0.33) | — | |
| SCHEMBL507894 | 0.77 | CYP1A2 (0.33) | TSHR | |
| SCHEMBL7262932 | 0.77 | — | — | |
| SCHEMBL7277057 | 0.77 | — | — | |
| SCHEMBL7900149 | 0.77 | — | — | |
| SCHEMBL6671659 | 0.76 | NR1H4 (0.42) | CA2CA1TSHRCA4CA6 | |
| SCHEMBL5979923 | 0.76 | PPARG (0.37) | TSHR | |
| SCHEMBL8715915 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583130-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0699196-A1 | CARBAZOLE DERIVATIVES WITH 17,20-LYASE-INHIBITING ACTIVITY | GLAXO GROUP LIMITED (GB) | 1996-03-06 | — | — | EP | disclosed |
| EP-0665748-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | — | 1995-08-23 | — | — | EP | disclosed |
| EP-0665748-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-08-09 | — | — | EP | disclosed |
| WO-1994027989-A1 | CARBAZOLE DERIVATIVES WITH 17,20-LYASE-INHIBITING ACTIVITY | GLAXO GROUP LIMITED (GB) | 1994-12-08 | — | — | WO | disclosed |
| WO-1994007486-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-04-14 | — | — | WO | disclosed |