Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5626209 | 0.96 | SNCA (0.71) | SNCAALDH1A1TSHRDAONAPRT | |
| Hydrochloric Acid SCHEMBL2446696 | 0.84 | SNCA (0.69) | SNCAALDH1A1TSHRANPEPCYP1A2 | |
| Hydrochloric Acid SCHEMBL1509558 | 0.82 | SNCA (0.58) | SNCAALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL10924988 | 0.81 | FOLH1 (0.56) | SNCAANPEPENPEPFOLH1NR4A2 | |
| Hydrochloric Acid SCHEMBL494 | 0.80 | SNCA (0.63) | SNCAALDH1A1TSHRANPEPCYP1A2 | |
| Bromide SCHEMBL39844 | 0.80 | SNCA (0.73) | SNCAALDH1A1TSHRANPEPCYP1A2 | |
| Iodide SCHEMBL9321342 | 0.80 | SNCA (0.69) | SNCAALDH1A1TSHRANPEPCYP1A2 | |
| SCHEMBL9133528 | 0.79 | TSHR (0.49) | SNCATSHR | |
| Bromide SCHEMBL2851873 | 0.79 | TSHR (0.50) | SNCAALDH1A1TSHRDAONAPRT | |
| Hydrochloric Acid SCHEMBL2069841 | 0.79 | SNCA (0.63) | SNCAALDH1A1TSHRANPEPCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-63303974-A | — | — | None | — | — | JP | disclosed |
| EP-0397697-B1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | RHONE POULENC RORER INT (US) | 1996-08-28 | — | — | EP | disclosed |
| US-5212182-A | Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics | AMERICAN HOME PRODUCTS CORPOORATION (US) | 1993-05-18 | — | — | US | disclosed |
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0397697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-07-03 | — | — | EP | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |
| EP-0397697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4?. | RORER INT OVERSEAS (US) | 1990-11-22 | — | — | EP | disclosed |
| US-4920130-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | RORER PHARAMCEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989004304-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |
| JP-S63303974-A | PRODUCTION OF NITROFURAN DERIVATIVE AND ITS SALT | TOOA SEIKATSU KAGAKU KENKYUSHO:KK | 1988-12-12 | — | — | JP | disclosed |