Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 5/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1989267 | 0.81 | MEN1 (0.42) | MAPTALDH1A1P2RX4P2RX1P2RX3 | |
| SCHEMBL1462848 | 0.80 | TSHR (0.32) | MAPTP2RX4P2RX1P2RX3SMN1; SMN2 | |
| SCHEMBL20987115 | 0.79 | MAPK1 (0.35) | P2RX4P2RX1P2RX3SMN1; SMN2NPSR1 | |
| SCHEMBL9030241 | 0.78 | P2RX4 (0.37) | MAPTALDH1A1P2RX4P2RX1P2RX3 | |
| SCHEMBL11534924 | 0.77 | KMT2A (0.41) | MAPTALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL1249047 | 0.77 | P2RX4 (0.31) | P2RX4MAPK1TSHRLMNASCN4A | |
| SCHEMBL1133635 | 0.75 | P2RX4 (0.41) | P2RX4P2RX1P2RX3SMN1; SMN2NPSR1 | |
| SCHEMBL9261043 | 0.75 | BRD4 (0.36) | ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL3122652 | 0.74 | P2RX4 (0.40) | ALDH1A1P2RX4P2RX1P2RX3SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29383470 | 0.74 | P2RX4 (0.40) | ALDH1A1P2RX4P2RX1P2RX3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1033584-C | Benzo-fused lactams that promote release of growth hormone | MERCK & CO INC (US) | 1996-12-18 | — | — | CN | disclosed |
| EP-0591255-B1 | TETRAHYDROBENZAZEPINE DERIVATIVES WHICH INHIBIT LIPOXYGENASE | PFIZER (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5478822-A | Tetrahydrobenzazepine derivatives which inhibit lipoxygenase | PFIZER INC. (US) | 1995-12-26 | — | — | US | disclosed |
| EP-0591255-A1 | TETRAHYDROBENZAZEPINE DERIVATIVES WHICH INHIBIT LIPOXYGENASE. | PFIZER (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000335-A1 | TETRAHYDROBENZAZEPINE DERIVATIVES WHICH INHIBIT LIPOXYGENASE | PFIZER INC. (US) | 1993-01-07 | — | — | WO | disclosed |