Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | CTSG | P08311 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | CTRC | Q99895 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032031 | 0.80 | SIGMAR1 (0.48) | LMNASIGMAR1CMA1ALDH1A1CHRM1 | |
| SCHEMBL9030962 | 0.78 | MAPT (0.38) | P2RX4LMNAMGLLALDH1A1MEN1 | |
| SCHEMBL9030464 | 0.78 | MAOA (0.35) | LMNABRD4GSK3AGSK3BMGLL | |
| SCHEMBL20987115 | 0.76 | MAPK1 (0.35) | P2RX4LMNASIGMAR1CHRM1MEN1 | |
| SCHEMBL1133635 | 0.76 | P2RX4 (0.41) | P2RX4LMNAMAPK1SMN1; SMN2P2RX1 | |
| Hydrochloric Acid SCHEMBL3122652 | 0.75 | P2RX4 (0.40) | P2RX4LMNAALDH1A1MAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29383470 | 0.75 | P2RX4 (0.40) | P2RX4LMNAALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL11534924 | 0.74 | KMT2A (0.41) | LMNANSD2ALDH1A1MEN1KMT2A | |
| SCHEMBL1462848 | 0.74 | TSHR (0.32) | P2RX4LMNAMEN1KMT2AMAPT | |
| SCHEMBL1249047 | 0.74 | P2RX4 (0.31) | P2RX4LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591255-B1 | TETRAHYDROBENZAZEPINE DERIVATIVES WHICH INHIBIT LIPOXYGENASE | PFIZER (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5478822-A | Tetrahydrobenzazepine derivatives which inhibit lipoxygenase | PFIZER INC. (US) | 1995-12-26 | — | — | US | disclosed |
| EP-0591255-A1 | TETRAHYDROBENZAZEPINE DERIVATIVES WHICH INHIBIT LIPOXYGENASE. | PFIZER (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000335-A1 | TETRAHYDROBENZAZEPINE DERIVATIVES WHICH INHIBIT LIPOXYGENASE | PFIZER INC. (US) | 1993-01-07 | — | — | WO | disclosed |