Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 8/20 | 0.54 |
| ▸ | AGTR2 | P50052 | 8/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9031747 | 0.91 | AGTR1 (0.63) | AGTR1AGTR2 | |
| SCHEMBL9033418 | 0.88 | — | — | |
| SCHEMBL9143472 | 0.87 | AGTR1 (0.68) | AGTR1AGTR2 | |
| SCHEMBL9033077 | 0.86 | AGTR1 (0.64) | AGTR1AGTR2 | |
| SCHEMBL9031879 | 0.86 | AGTR1 (0.59) | AGTR1AGTR2 | |
| SCHEMBL9034096 | 0.86 | AGTR1 (0.54) | AGTR1AGTR2 | |
| SCHEMBL9032970 | 0.85 | AGTR1 (0.66) | AGTR1AGTR2 | |
| SCHEMBL7833154 | 0.85 | AGTR1 (0.71) | AGTR1AGTR2 | |
| SCHEMBL9032073 | 0.85 | — | — | |
| SCHEMBL7398483 | 0.84 | AGTR1 (0.72) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412594-B1 | Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists | MERCK & CO INC (US) | 1996-01-03 | — | — | EP | disclosed |
| US-5411980-A | Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists | MERCK & CO., INC. (US) | 1995-05-02 | — | — | US | disclosed |
| US-5250558-A | Substituted triazolinones, triazolinethiones, and triazolinimines as neurotensin antagonists used to treat psychosis | MERCK & CO., INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0412594-A2 | Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists | MERCK & CO. INC. (US) | 1991-02-13 | — | — | EP | disclosed |