Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 4/20 | 0.33 |
| ▸ | CES1 | P23141 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032002 | 0.83 | ALDH1A1 (0.40) | KMT2AALDH1A1 | |
| SCHEMBL9031995 | 0.83 | ALDH1A1 (0.40) | KMT2AALDH1A1 | |
| SCHEMBL9031327 | 0.82 | KDM4E (0.34) | KMT2AACEGPR139ALDH1A1 | |
| SCHEMBL9032933 | 0.82 | KDM4E (0.34) | KMT2AACEGPR139ALDH1A1 | |
| SCHEMBL9030932 | 0.78 | ACE (0.33) | ACEALDH1A1 | |
| SCHEMBL9032393 | 0.78 | ACE (0.33) | ACEALDH1A1 | |
| SCHEMBL9032621 | 0.78 | ACE (0.33) | ACEALDH1A1 | |
| SCHEMBL9032401 | 0.78 | ACE (0.33) | ACEALDH1A1 | |
| SCHEMBL9030883 | 0.78 | ACE (0.33) | ACEALDH1A1 | |
| SCHEMBL9032350 | 0.73 | USP2 (0.30) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558287-B1 | Tetrahydrothiophene derivatives | SANTEN PHARMACEUTICAL CO LTD (JP) | 1996-12-04 | — | — | EP | disclosed |
| US-5292767-A | Tetrahydrothiophene derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0558287-A1 | Tetrahydrothiophene derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1993-09-01 | — | — | EP | disclosed |