Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9031995 | 1.00 | ALDH1A1 (0.40) | ALDH1A1HSD17B10MEN1KMT2AKCNH2 | |
| SCHEMBL9032933 | 0.84 | KDM4E (0.34) | ALDH1A1HSD17B10KMT2ANPC1KDM4E | |
| SCHEMBL9031327 | 0.84 | KDM4E (0.34) | ALDH1A1HSD17B10KMT2ANPC1KDM4E | |
| SCHEMBL9031835 | 0.83 | KMT2A (0.36) | ALDH1A1KMT2A | |
| SCHEMBL9031900 | 0.82 | ALDH1A1 (0.49) | ALDH1A1HSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL9031895 | 0.82 | ALDH1A1 (0.49) | ALDH1A1HSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL9032617 | 0.82 | PDK1 (0.36) | ALDH1A1MEN1KMT2A | |
| SCHEMBL9031410 | 0.81 | ALDH1A1 (0.38) | ALDH1A1HSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL9031417 | 0.81 | ALDH1A1 (0.38) | ALDH1A1HSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL9032169 | 0.78 | ALDH1A1 (0.43) | ALDH1A1NPC1SMN1; SMN2HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558287-B1 | Tetrahydrothiophene derivatives | SANTEN PHARMACEUTICAL CO LTD (JP) | 1996-12-04 | — | — | EP | disclosed |
| US-5292767-A | Tetrahydrothiophene derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0558287-A1 | Tetrahydrothiophene derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1993-09-01 | — | — | EP | disclosed |