Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 4/20 | 0.41 |
| ▸ | ATP4B | P51164 | 4/20 | 0.41 |
| ▸ | LTA4H | P09960 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9031383 | 1.00 | ATP4A (0.41) | ATP4AATP4BLTA4HMAPTSMN1; SMN2 | |
| SCHEMBL9032163 | 1.00 | ATP4A (0.41) | ATP4AATP4BLTA4HMAPTSMN1; SMN2 | |
| SCHEMBL9032465 | 0.86 | NPC1 (0.44) | MAPTSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL9032458 | 0.86 | NPC1 (0.44) | MAPTSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL9032333 | 0.85 | PPARG (0.55) | — | |
| SCHEMBL9032832 | 0.85 | PPARG (0.55) | — | |
| SCHEMBL9429664 | 0.85 | PPARG (0.55) | — | |
| SCHEMBL9311972 | 0.85 | PPARG (0.55) | — | |
| SCHEMBL9429676 | 0.84 | PPARG (0.45) | LTA4HMAPTNPC1RAB9AKCNH2 | |
| SCHEMBL9311984 | 0.84 | PPARG (0.45) | LTA4HMAPTNPC1RAB9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528734-B1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-10-23 | — | — | EP | disclosed |
| US-5330999-A | Diabetes, obesity | ADIR ET COMPAGNIE (FR) | 1994-07-19 | — | — | US | disclosed |
| US-5296605-A | 2,4-thiazolidinedione compounds | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5266582-A | Antidiabetic agents | ADIR ET COMPAGNIE (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0528734-A1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-02-24 | — | — | EP | disclosed |