Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 11/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SI | P14410 | 1/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9311972 | 1.00 | PPARG (0.55) | PPARGHPGDHDAC4HDAC8PTPN11 | |
| SCHEMBL9032333 | 1.00 | PPARG (0.55) | PPARGHPGDHDAC4HDAC8PTPN11 | |
| SCHEMBL9429664 | 1.00 | PPARG (0.55) | PPARGHPGDHDAC4HDAC8PTPN11 | |
| SCHEMBL9429676 | 0.91 | PPARG (0.45) | PPARGHPGDHDAC4HDAC8PTPN11 | |
| SCHEMBL9311984 | 0.91 | PPARG (0.45) | PPARGHPGDHDAC4HDAC8PTPN11 | |
| SCHEMBL9031959 | 0.88 | HPGD (0.48) | PPARGHPGD | |
| SCHEMBL9031952 | 0.88 | HPGD (0.48) | PPARGHPGD | |
| SCHEMBL9032154 | 0.85 | ATP4A (0.41) | — | |
| SCHEMBL9031383 | 0.85 | ATP4A (0.41) | — | |
| SCHEMBL9032163 | 0.85 | ATP4A (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528734-B1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-10-23 | — | — | EP | disclosed |
| US-5330999-A | Diabetes, obesity | ADIR ET COMPAGNIE (FR) | 1994-07-19 | — | — | US | disclosed |
| US-5296605-A | 2,4-thiazolidinedione compounds | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5266582-A | Antidiabetic agents | ADIR ET COMPAGNIE (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0528734-A1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-02-24 | — | — | EP | disclosed |