Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | ATP4A | P20648 | 4/20 | 0.41 |
| ▸ | ATP4B | P51164 | 4/20 | 0.41 |
| ▸ | LTA4H | P09960 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | PTGES | O14684 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032183 | 1.00 | CHRNA7 (0.43) | CHRNA7HTR3AATP4AATP4BLTA4H | |
| SCHEMBL9032763 | 0.84 | HPGD (0.53) | — | |
| SCHEMBL9311188 | 0.84 | HPGD (0.53) | — | |
| SCHEMBL9311201 | 0.83 | HPGD (0.43) | CHRNA7HTR3AATP4AATP4B | |
| SCHEMBL5021501 | 0.83 | CHRNA7 (0.48) | CHRNA7HTR3AALDH1A1TSHRLMNA | |
| SCHEMBL8507531 | 0.79 | PDE10A (0.47) | CHRNA7 | |
| SCHEMBL8508526 | 0.79 | PDE10A (0.47) | CHRNA7 | |
| SCHEMBL9031383 | 0.78 | ATP4A (0.41) | ATP4AATP4BLTA4HALDH1A1LMNA | |
| SCHEMBL9032154 | 0.78 | ATP4A (0.41) | ATP4AATP4BLTA4HALDH1A1LMNA | |
| SCHEMBL9032163 | 0.78 | ATP4A (0.41) | ATP4AATP4BLTA4HALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528734-B1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-10-23 | — | — | EP | disclosed |
| US-5330999-A | Diabetes, obesity | ADIR ET COMPAGNIE (FR) | 1994-07-19 | — | — | US | disclosed |
| US-5296605-A | 2,4-thiazolidinedione compounds | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5266582-A | Antidiabetic agents | ADIR ET COMPAGNIE (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0528734-A1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-02-24 | — | — | EP | disclosed |