Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | GAPDH | P04406 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9032046 | 0.98 | TAAR1 (0.39) | TAAR1HTR2AHTR2CMEN1RAD52 | |
| SCHEMBL30940213 | 0.81 | — | — | |
| SCHEMBL3466429 | 0.74 | TYR (0.37) | MEN1KMT2ATDP1MAPTALOX15 | |
| SCHEMBL17783706 | 0.74 | MAPT (0.33) | MAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL6643071 | 0.74 | TAAR1 (0.38) | TAAR1HTR2AHTR2CMEN1RAD52 | |
| SCHEMBL2592432 | 0.73 | — | — | |
| SCHEMBL23094091 | 0.72 | MAPT (0.33) | MAPTL3MBTL1 | |
| SCHEMBL16760670 | 0.72 | MAPT (0.33) | MAPTL3MBTL1 | |
| SCHEMBL4235310 | 0.72 | MAPT (0.33) | MAPTL3MBTL1 | |
| SCHEMBL3469023 | 0.72 | MAPT (0.33) | MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398504-B1 | Thieno[3,4-d]azepine derivatives, process for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LTD (GB) | 1996-06-19 | — | — | EP | disclosed |
| US-5028602-A | Thieno-(3,4-d)azepines, central nervous system disorders | LILLY INDUSTRIES LIMITED (GB) | 1991-07-02 | — | — | US | disclosed |
| EP-0398504-A1 | Thieno[3,4-d]azepine derivatives, process for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LIMITED (GB) | 1990-11-22 | — | — | EP | disclosed |