SCHEMBL9032292

SCHEMBL9032292

COC(=O)c1sc(C)c2nc(C(F)(F)F)n(Cc3ccc(-c4ccccc4-c4nnn[nH]4)cc3)c12

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 3/20 0.38
AGTR2 P50052 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9032321 0.94 AGTR1 (0.38) AGTR1AGTR2
SCHEMBL9031708 0.92 AGTR1 (0.36) AGTR1AGTR2
SCHEMBL9033410 0.89 AGTR1 (0.40) AGTR1AGTR2
SCHEMBL9031955 0.88 AGTR1 (0.39) AGTR1AGTR2
SCHEMBL9029966 0.86 AGTR1 (0.38) AGTR1AGTR2
SCHEMBL9032855 0.86 AGTR1 (0.45) AGTR1AGTR2
SCHEMBL9031512 0.86 AGTR1 (0.40) AGTR1AGTR2
SCHEMBL9031293 0.86 AGTR1 (0.42) AGTR1AGTR2
SCHEMBL9029855 0.86 AGTR1 (0.41) AGTR1AGTR2
SCHEMBL9262033 0.86 AGTR1 (0.38) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0483683-B1 Thienoimidazole derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1996-02-28 EP disclosed
US-5463073-A Angiotensin II antagonists TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-10-31 US disclosed
EP-0483683-A2 Thienoimidazole derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1992-05-06 EP disclosed