Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.74 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.55 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.55 |
| ▸ | SRC | P12931 | 7/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | EGFR | P00533 | 6/20 | 0.53 |
| ▸ | FLT4 | P35916 | 3/20 | 0.53 |
| ▸ | MET | P08581 | 3/20 | 0.53 |
| ▸ | RET | P07949 | 3/20 | 0.53 |
| ▸ | FLT3 | P36888 | 3/20 | 0.53 |
| ▸ | CIT | O14578 | 2/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.53 |
| ▸ | STK10 | O94804 | 2/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14289180 | 0.85 | AXL (1.00) | AXLSRCKDREGFRFLT4 | |
| SCHEMBL30000966 | 0.85 | AXL (1.00) | AXLSRCKDREGFRFLT4 | |
| SCHEMBL166239 | 0.85 | AXL (1.00) | AXLSRCKDREGFRFLT4 | |
| SCHEMBL12469296 | 0.84 | AXL (0.73) | AXLEHMT2EHMT1SRCKDR | |
| SCHEMBL10046591 | 0.83 | AXL (0.72) | AXLEHMT2EHMT1SRCKDR | |
| SCHEMBL13679438 | 0.83 | KIT (0.53) | AXLEHMT2EHMT1SRCMET | |
| SCHEMBL900298 | 0.81 | AXL (0.69) | AXLEHMT2EHMT1SRCKDR | |
| SCHEMBL13667704 | 0.81 | AXL (0.68) | AXLSRCEGFRMETRIPK2 | |
| SCHEMBL14289192 | 0.81 | AXL (0.92) | AXLSRCKDREGFRFLT4 | |
| SCHEMBL1591152 | 0.81 | AXL (0.92) | AXLSRCKDREGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044577-A1 | DUAL INHIBITORS OF MET AND VEGF FOR THE TREATMENT OF CASTRATION RESISTANT PROSTATE CANCER AND OSTEOBLASTIC BONE METASTASES | EXELIXIS, INC. (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2010065838-A1 | METHODS OF PREPARING QUINOLINE DERIVATIVES | EXELIXIS, INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| WO-2008035209-A2 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | METHYLGENE INC. (CA) | 2008-03-27 | — | — | WO | disclosed |