Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.72 |
| ▸ | RET | P07949 | 3/20 | 0.54 |
| ▸ | KIF5B | P33176 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 9/20 | 0.54 |
| ▸ | SRC | P12931 | 6/20 | 0.54 |
| ▸ | KDR | P35968 | 6/20 | 0.54 |
| ▸ | FLT3 | P36888 | 3/20 | 0.54 |
| ▸ | FLT4 | P35916 | 3/20 | 0.54 |
| ▸ | MET | P08581 | 3/20 | 0.54 |
| ▸ | CIT | O14578 | 2/20 | 0.54 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.54 |
| ▸ | STK10 | O94804 | 2/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166239 | 0.84 | AXL (1.00) | AXLRETEGFRSRCKDR | |
| SCHEMBL30000966 | 0.84 | AXL (1.00) | AXLRETEGFRSRCKDR | |
| SCHEMBL14289180 | 0.84 | AXL (1.00) | AXLRETEGFRSRCKDR | |
| SCHEMBL903267 | 0.83 | AXL (0.74) | AXLRETKIF5BEGFRSRC | |
| SCHEMBL12469296 | 0.82 | AXL (0.73) | AXLRETKIF5BEGFRSRC | |
| SCHEMBL900298 | 0.80 | AXL (0.69) | AXLRETEGFRSRCKDR | |
| SCHEMBL1591152 | 0.79 | AXL (0.92) | AXLRETEGFRSRCKDR | |
| SCHEMBL14289192 | 0.79 | AXL (0.92) | AXLRETEGFRSRCKDR | |
| SCHEMBL29908856 | 0.79 | AXL (0.92) | AXLRETEGFRSRCKDR | |
| SCHEMBL13380202 | 0.79 | AXL (0.65) | AXLRETKIF5BEGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009723-A1 | C-MET MODULATOR PHARMACEUTICAL COMPOSITIONS | EXELIXIS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |