Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032312 | 0.97 | KDM4E (0.50) | ADORA3KDM4EGAACACNA1FCACNA1D | |
| SCHEMBL9032030 | 0.94 | KDM4E (0.47) | ADORA3KDM4EGAACACNA1FCACNA1D | |
| SCHEMBL9034602 | 0.85 | MAPT (0.62) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9034599 | 0.85 | MAPT (0.62) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL8197541 | 0.84 | ADORA3 (0.71) | ADORA3KDM4EGAACACNA1FCACNA1D | |
| SCHEMBL9031625 | 0.84 | CACNA1C (0.53) | ADORA3KDM4EGAACACNA1FCACNA1D | |
| SCHEMBL9032772 | 0.83 | ADORA3 (0.55) | ADORA3KDM4EGAACACNA1FCACNA1D | |
| SCHEMBL9427365 | 0.83 | GPBAR1 (0.40) | KDM4EGAACACNA1FCACNA1DCACNA1S | |
| SCHEMBL9033145 | 0.82 | POLB (0.54) | ADORA3KDM4EGAACACNA1FCACNA1D | |
| SCHEMBL9032084 | 0.82 | ABCB11 (0.56) | ADORA3KDM4EGAACACNA1FCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474129-B1 | 1,4-Dihydropyridine derivatives and process for preparing the same | ACHIWA KAZUO (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5336774-A | 1,4-dihydropyridine 3,5 carboxyl compounds | ACHIWA KAZUO (JP) | 1994-08-09 | — | — | US | disclosed |
| US-5234821-A | Process for preparing 1,4 dihydropyridine compounds | ACHIWA KAZUO (JP) | 1993-08-10 | — | — | US | disclosed |
| EP-0474129-A2 | 1,4-Dihydropyridine derivatives and process for preparing the same | Achiwa, Kazuo (JP) | 1992-03-11 | — | — | EP | disclosed |