Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | FNTA | P49354 | 5/20 | 0.53 |
| ▸ | FNTB | P49356 | 5/20 | 0.53 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033213 | 1.00 | OPRM1 (0.53) | OPRM1OPRD1OPRK1FNTAFNTB | |
| SCHEMBL9033208 | 1.00 | OPRM1 (0.53) | OPRM1OPRD1OPRK1FNTAFNTB | |
| SCHEMBL5482120 | 1.00 | OPRM1 (0.53) | OPRM1OPRD1OPRK1FNTAFNTB | |
| SCHEMBL6428974 | 0.85 | OPRM1 (0.54) | OPRM1OPRD1OPRK1KMT2AMEN1 | |
| SCHEMBL6431468 | 0.85 | OPRM1 (0.54) | OPRM1OPRD1OPRK1KMT2AMEN1 | |
| SCHEMBL6431423 | 0.85 | OPRM1 (0.54) | OPRM1OPRD1OPRK1KMT2AMEN1 | |
| SCHEMBL6431289 | 0.84 | MEN1 (0.61) | OPRM1OPRD1OPRK1KMT2AMEN1 | |
| SCHEMBL6432366 | 0.83 | OPRM1 (0.57) | OPRM1OPRD1OPRK1KMT2AMEN1 | |
| SCHEMBL31037193 | 0.83 | OPRM1 (0.57) | OPRM1OPRD1OPRK1KMT2AMEN1 | |
| SCHEMBL6368127 | 0.83 | OPRM1 (0.57) | OPRM1OPRD1OPRK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696593-A2 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-02-14 | — | — | EP | disclosed |
| EP-0675112-A1 | Imidazole-containing inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-10-04 | — | — | EP | disclosed |
| EP-0618221-A2 | Heterocyclic inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-10-05 | — | — | EP | disclosed |