Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624953 | 0.88 | ALDH1A1 (0.37) | MMP3GLASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL7395028 | 0.81 | SMN1; SMN2 (0.46) | GLASMN1; SMN2ALDH1A1KEAP1KDM4E | |
| SCHEMBL6446184 | 0.78 | GLA (0.40) | MMP3GLASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL10401216 | 0.75 | ALDH1A1 (0.43) | GLASMN1; SMN2ALDH1A1KEAP1KDM4E | |
| SCHEMBL27660398 | 0.74 | SMN1; SMN2 (0.44) | GLASMN1; SMN2ALDH1A1KEAP1KDM4E | |
| SCHEMBL684590 | 0.73 | ALDH1A1 (0.42) | GLASMN1; SMN2ALDH1A1KEAP1KDM4E | |
| SCHEMBL25452781 | 0.72 | GLA (0.37) | MMP3GLASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL18123341 | 0.72 | ALDH1A1 (0.41) | GLASMN1; SMN2ALDH1A1KEAP1KDM4E | |
| SCHEMBL9033237 | 0.71 | GLA (0.38) | GLASMN1; SMN2ALDH1A1KEAP1KDM4E | |
| SCHEMBL24937717 | 0.71 | SMN1; SMN2 (0.40) | MMP3GLASMN1; SMN2ALDH1A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705835-A1 | Quinoxalic-2,3-diones with an oxa or thiaheterocyclic fused ring | CIBA-GEIGY AG (CH) | 1996-04-10 | — | — | EP | disclosed |
| EP-0705834-A1 | Quinoxaline-2,3-diones with an azaheterocyclic fused ring | CIBA-GEIGY AG (CH) | 1996-04-10 | — | — | EP | disclosed |