Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033244 | 0.88 | MMP3 (0.38) | ALDH1A1MAPK1SIGMAR1CYP1A2CHRM2 | |
| SCHEMBL6608168 | 0.82 | SMN1; SMN2 (0.53) | ALDH1A1SIGMAR1HRH3SMN1; SMN2CA12 | |
| SCHEMBL6446184 | 0.77 | GLA (0.40) | ALDH1A1GLASMN1; SMN2KEAP1KDM4E | |
| SCHEMBL14300251 | 0.74 | ALDH1A1 (0.41) | ALDH1A1MAPK1SIGMAR1CYP1A2CHRM2 | |
| SCHEMBL23223379 | 0.73 | SIGMAR1 (0.40) | ALDH1A1MAPK1SIGMAR1CYP1A2CHRM2 | |
| SCHEMBL7395028 | 0.73 | SMN1; SMN2 (0.46) | ALDH1A1TSHRGLASMN1; SMN2USP2 | |
| SCHEMBL27660398 | 0.73 | SMN1; SMN2 (0.44) | ALDH1A1MAPK1GLASMN1; SMN2LMNA | |
| SCHEMBL2916 | 0.72 | — | — | |
| SCHEMBL25452781 | 0.71 | GLA (0.37) | ALDH1A1TSHRGLASMN1; SMN2KDM4E | |
| SCHEMBL24937717 | 0.70 | SMN1; SMN2 (0.40) | ALDH1A1TSHRGLASMN1; SMN2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444201-A1 | 2-(3-SULFONYLAMINO-2-OXOPYRROLIDIN-1-YL)PROPANAMIDES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003043981-A1 | 2-(3-SULFONYLAMINO-2-OXOPYRROLIDIN-1-YL)PROPANAMIDES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-05-30 | — | — | WO | disclosed |