Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.49 |
| ▸ | CDK2 | P24941 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14564447 | 0.82 | MEN1 (0.55) | GSK3BCDK2GAAFBP1IDO1 | |
| SCHEMBL1931754 | 0.81 | GAA (0.65) | GSK3BCDK2GAAFBP1ADORA2A | |
| SCHEMBL6372051 | 0.81 | ADORA2A (0.60) | GSK3BCDK2GAAFBP1ADORA2A | |
| SCHEMBL27905112 | 0.81 | KDM4E (0.47) | GSK3BCDK2GAAFBP1ADORA2A | |
| SCHEMBL1969272 | 0.81 | ADORA2A (0.64) | GSK3BCDK2GAAFBP1ADORA2A | |
| SCHEMBL9684703 | 0.81 | PTGIR (0.43) | GSK3BCYP4F2CYP4A11 | |
| SCHEMBL9722654 | 0.80 | GSK3B (0.55) | GSK3BCDK2GAAFBP1ADORA2A | |
| SCHEMBL11663626 | 0.78 | GSK3B (0.50) | GSK3BCDK2GAAFBP1IDO1 | |
| SCHEMBL13180624 | 0.78 | ALPL (0.51) | GSK3BCDK2GAAFBP1IDO1 | |
| SCHEMBL13150796 | 0.78 | GSK3B (0.61) | GSK3BCDK2FBP1ADORA2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682654-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1996-01-17 | — | — | EP | disclosed |
| EP-0682654-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1994018169-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| US-5284841-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1994-02-08 | — | — | US | disclosed |