Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9034239 | 0.97 | CYP2C9 (0.58) | CYP2C9KDM4EMEN1CYP1A2CYP3A4 | |
| SCHEMBL9032248 | 0.85 | CYP2C9 (0.51) | CYP2C9KDM4EMEN1CYP1A2CYP3A4 | |
| SCHEMBL9032779 | 0.84 | CYP2C9 (0.57) | CYP2C9KDM4EMEN1CYP1A2CYP3A4 | |
| SCHEMBL9034198 | 0.84 | CYP2C9 (0.69) | CYP2C9KDM4EMEN1CYP1A2CYP3A4 | |
| SCHEMBL9032128 | 0.82 | ABCB11 (0.52) | CYP2C9KDM4EMEN1CYP1A2CYP3A4 | |
| SCHEMBL9032902 | 0.81 | ABCB11 (0.48) | CYP2C9KDM4EMEN1CYP1A2CYP3A4 | |
| SCHEMBL9034077 | 0.80 | CACNA1F (0.51) | KDM4ECYP3A4ALDH1A1HPGDTP53 | |
| SCHEMBL9032084 | 0.80 | ABCB11 (0.56) | CYP2C9KDM4EMEN1CYP1A2CYP3A4 | |
| SCHEMBL9032772 | 0.78 | ADORA3 (0.55) | CYP2C9KDM4EMEN1CYP1A2CYP3A4 | |
| SCHEMBL9034637 | 0.78 | CACNA1C (0.56) | CYP2C9KDM4EMEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474129-B1 | 1,4-Dihydropyridine derivatives and process for preparing the same | ACHIWA KAZUO (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5336774-A | 1,4-dihydropyridine 3,5 carboxyl compounds | ACHIWA KAZUO (JP) | 1994-08-09 | — | — | US | disclosed |
| US-5234821-A | Process for preparing 1,4 dihydropyridine compounds | ACHIWA KAZUO (JP) | 1993-08-10 | — | — | US | disclosed |
| EP-0474129-A2 | 1,4-Dihydropyridine derivatives and process for preparing the same | Achiwa, Kazuo (JP) | 1992-03-11 | — | — | EP | disclosed |