Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 15/20 | 0.61 |
| ▸ | DRD2 | P14416 | 14/20 | 0.61 |
| ▸ | DRD3 | P35462 | 12/20 | 0.61 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8919044 | 0.88 | DRD4 (0.80) | DRD4DRD2DRD3MBTD1L3MBTL3 | |
| SCHEMBL8786329 | 0.82 | DRD4 (0.81) | DRD4DRD2DRD3 | |
| SCHEMBL8786997 | 0.77 | DRD2 (1.00) | DRD4DRD2DRD3OPRM1OPRK1 | |
| SCHEMBL8915671 | 0.76 | DRD4 (0.80) | DRD4DRD2DRD3OPRM1OPRK1 | |
| SCHEMBL8916449 | 0.76 | DRD4 (0.84) | DRD4DRD2DRD3OPRM1OPRK1 | |
| SCHEMBL8915781 | 0.74 | DRD4 (0.77) | DRD4DRD2DRD3OPRM1 | |
| SCHEMBL8919697 | 0.74 | DRD4 (0.76) | DRD4DRD2DRD3OPRM1OPRK1 | |
| SCHEMBL8786461 | 0.71 | DRD2 (0.87) | DRD4DRD2DRD3OPRM1OPRK1 | |
| SCHEMBL8786338 | 0.71 | DRD4 (0.83) | DRD4DRD2DRD3 | |
| SCHEMBL8786476 | 0.70 | DRD4 (1.00) | DRD4DRD2DRD3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719264-A1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1996-07-03 | — | — | EP | disclosed |
| WO-1995007904-A1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-23 | — | — | WO | disclosed |