Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11738755 | 0.84 | OPRL1 (0.69) | OPRL1POLBOPRM1SIGMAR1CYP3A4 | |
| SCHEMBL17982780 | 0.84 | CYP3A4 (0.51) | OPRL1POLBOPRM1SIGMAR1CYP3A4 | |
| SCHEMBL31158331 | 0.84 | CYP3A4 (0.51) | OPRL1POLBOPRM1SIGMAR1CYP3A4 | |
| Hydrochloric Acid SCHEMBL11744428 | 0.82 | POLB (0.70) | OPRL1POLBOPRM1SIGMAR1CYP3A4 | |
| SCHEMBL6042326 | 0.81 | OPRL1 (0.66) | OPRL1POLBOPRM1SIGMAR1CYP3A4 | |
| SCHEMBL17799025 | 0.80 | OPRL1 (0.55) | OPRL1POLBOPRM1SIGMAR1CYP3A4 | |
| SCHEMBL23660796 | 0.78 | OPRM1 (0.69) | OPRL1OPRM1SIGMAR1CYP3A4TSHR | |
| SCHEMBL31158302 | 0.78 | TSHR (0.54) | OPRL1POLBSIGMAR1CYP3A4TSHR | |
| SCHEMBL23647439 | 0.78 | TSHR (0.54) | OPRL1POLBSIGMAR1CYP3A4TSHR | |
| SCHEMBL11743900 | 0.75 | SIGMAR1 (0.66) | OPRL1POLBOPRM1SIGMAR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2015061-A | — | — | None | — | — | JP | disclosed |
| US-20140335050-A1 | METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER | THE GENERAL HOSPITAL CORPORATION (US) | 2014-11-13 | — | — | US | disclosed |
| EP-0315405-B1 | 4-phenyl-4-(N-(2-fluorophenyl)amido) piperidine derivatives | OHMEDA PHARMA PROD (US) | 1996-01-24 | — | — | EP | disclosed |
| US-5013742-A | Analgesics, Anesthetics, Narcotic Antagonists | BOC, INC. (US) | 1991-05-07 | — | — | US | disclosed |
| US-4957929-A | ANALGESICS, ANESTHETICS | BOC, INC. (US) | 1990-09-18 | — | — | US | disclosed |
| US-4921864-A | 4-Phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds | BOC, INC. (US) | 1990-05-01 | — | — | US | disclosed |
| JP-H0215061-A | 4-PHENYL-4-(N-(PHENYL)AMIDE)PIPERIDINE DERIVATIVE AND PREPARATION COMPOSITION CONTAINING THE SAME | BOC GROUP INC:THE | 1990-01-18 | — | — | JP | disclosed |
| EP-0315405-A1 | 4-phenyl-4-(N-(2-fluorophenyl)amido) piperidine derivatives | Ohmeda Pharmaceutical Products Division Inc. (US) | 1989-05-10 | — | — | EP | disclosed |
| US-4791121-A | ANALGESICS | THE BOC GROUP, INC. (US) | 1988-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140335050-A1 | METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER | IL2RA, CD74, IL2 | OPRL1 116/4885POLB 3364/4885OPRM1 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.