Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ENO1 | P06733 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033584 | 0.95 | POLB (0.36) | TSHRLMNATP53SMN1; SMN2KDM4E | |
| SCHEMBL7159469 | 0.82 | KDM4E (0.57) | TSHRLMNATP53SMN1; SMN2KDM4E | |
| SCHEMBL11838136 | 0.80 | KDM4E (0.59) | TSHRLMNATP53SMN1; SMN2KDM4E | |
| SCHEMBL9046931 | 0.79 | TSHR (0.37) | TSHRTP53KDM4ENPSR1POLB | |
| SCHEMBL9032463 | 0.79 | KDM4E (0.62) | TSHRLMNATP53SMN1; SMN2KDM4E | |
| SCHEMBL7158370 | 0.75 | TSHR (0.61) | TSHRLMNATP53SMN1; SMN2KDM4E | |
| SCHEMBL9033075 | 0.74 | KDM4E (0.55) | TSHRLMNATP53SMN1; SMN2KDM4E | |
| SCHEMBL9033301 | 0.74 | KDM4E (0.55) | TSHRLMNASMN1; SMN2KDM4EPOLB | |
| SCHEMBL9032390 | 0.73 | TSHR (0.43) | TSHRLMNATP53SMN1; SMN2KDM4E | |
| SCHEMBL9032382 | 0.72 | TSHR (0.42) | TSHRLMNATP53SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474129-B1 | 1,4-Dihydropyridine derivatives and process for preparing the same | ACHIWA KAZUO (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5336774-A | 1,4-dihydropyridine 3,5 carboxyl compounds | ACHIWA KAZUO (JP) | 1994-08-09 | — | — | US | disclosed |
| US-5234821-A | Process for preparing 1,4 dihydropyridine compounds | ACHIWA KAZUO (JP) | 1993-08-10 | — | — | US | disclosed |
| EP-0474129-A2 | 1,4-Dihydropyridine derivatives and process for preparing the same | Achiwa, Kazuo (JP) | 1992-03-11 | — | — | EP | disclosed |