Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032463 | 0.94 | KDM4E (0.62) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL9033075 | 0.89 | KDM4E (0.55) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL8197541 | 0.81 | ADORA3 (0.71) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL9831380 | 0.80 | KDM4E (0.86) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL8106730 | 0.80 | KDM4E (0.86) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL9831160 | 0.79 | KDM4E (0.64) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL3775215 | 0.76 | KDM4E (0.62) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL8203346 | 0.76 | CACNA1C (0.71) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL8198332 | 0.76 | ABCB11 (0.74) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL9034838 | 0.74 | TSHR (0.39) | KDM4ELMNAALDH1A1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474129-B1 | 1,4-Dihydropyridine derivatives and process for preparing the same | ACHIWA KAZUO (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5336774-A | 1,4-dihydropyridine 3,5 carboxyl compounds | ACHIWA KAZUO (JP) | 1994-08-09 | — | — | US | disclosed |
| US-5234821-A | Process for preparing 1,4 dihydropyridine compounds | ACHIWA KAZUO (JP) | 1993-08-10 | — | — | US | disclosed |
| EP-0474129-A2 | 1,4-Dihydropyridine derivatives and process for preparing the same | Achiwa, Kazuo (JP) | 1992-03-11 | — | — | EP | disclosed |