Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 15/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9034189 | 0.89 | AR (0.43) | ARIMPDH2ALDH1A1KDM4EUSP2 | |
| SCHEMBL3375489 | 0.86 | MAOB (0.45) | ARIMPDH2ALDH1A1KDM4EACHE | |
| SCHEMBL2614475 | 0.79 | AR (0.69) | ARIMPDH2ALDH1A1KDM4EUSP2 | |
| SCHEMBL4595417 | 0.75 | MAOB (0.48) | ARIMPDH2ALDH1A1KDM4EACHE | |
| SCHEMBL2554271 | 0.74 | AR (0.46) | AR | |
| SCHEMBL1776690 | 0.74 | AR (0.57) | ARALDH1A1KDM4E | |
| SCHEMBL8799276 | 0.73 | NOS2 (0.43) | ALDH1A1KDM4EUSP2 | |
| SCHEMBL21246251 | 0.73 | AR (0.45) | ARIMPDH2ALDH1A1 | |
| SCHEMBL13481169 | 0.73 | AR (0.49) | AR | |
| SCHEMBL9034950 | 0.71 | NPC1 (0.51) | ARIMPDH2ALDH1A1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365328-B1 | Pyridine derivatives | ZENECA LTD (GB) | 1996-04-03 | — | — | EP | claimed |
| US-5053415-A | Antiischemic, antiinflammatory, antiarthritic agents, cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-10-01 | — | — | US | claimed |
| EP-0365328-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1990-04-25 | — | — | EP | claimed |
| EP-0365328-B1 | Pyridine derivatives | ZENECA LTD (GB) | 1996-04-03 | — | — | EP | disclosed |
| US-5053415-A | Antiischemic, antiinflammatory, antiarthritic agents, cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-10-01 | — | — | US | disclosed |
| EP-0365328-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1990-04-25 | — | — | EP | disclosed |