Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 3/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | CFD | P00746 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3375489 | 0.90 | MAOB (0.45) | MAOBALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9034189 | 0.86 | AR (0.43) | MAOBALDH1A1KDM4EARIMPDH2 | |
| SCHEMBL11464186 | 0.84 | ALDH1A1 (0.47) | MAOBALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4595414 | 0.83 | ALDH1A1 (0.43) | MAOBALDH1A1RAB9ANPC1KDM4E | |
| SCHEMBL4324072 | 0.81 | ALDH1A1 (0.62) | MAOBALDH1A1RAB9ALMNAS1PR1 | |
| SCHEMBL1667669 | 0.81 | CFD (0.47) | MAOBALDH1A1RAB9AS1PR1TSHR | |
| SCHEMBL6175873 | 0.81 | MAOB (0.47) | MAOBALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16421474 | 0.81 | ALDH1A1 (0.50) | MAOBALDH1A1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL13946931 | 0.79 | MAOB (0.45) | MAOBALDH1A1RAB9ASMN1; SMN2S1PR1 | |
| SCHEMBL8007448 | 0.78 | RAB9A (0.49) | MAOBALDH1A1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945646-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Cellzome (UK) Ltd. (GB) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007039467-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | CELLZOME (UK) LTD. (GB) | 2007-04-12 | — | — | WO | disclosed |