Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 9/20 | 0.44 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9037321 | 0.92 | TSHR (0.46) | TSHRPPARAABCB11CYP1A2CYP3A4 | |
| SCHEMBL21991780 | 0.81 | TSHR (0.51) | TSHRPPARAABCB11CYP1A2CYP3A4 | |
| SCHEMBL30229615 | 0.81 | TSHR (0.51) | TSHRPPARAABCB11CYP1A2CYP3A4 | |
| SCHEMBL10207532 | 0.79 | PPARA (0.52) | TSHRPPARAABCB11CYP1A2CYP3A4 | |
| SCHEMBL9034965 | 0.79 | FBP1 (0.61) | TSHRPPARAABCB11CYP1A2CYP3A4 | |
| SCHEMBL11439123 | 0.77 | FFAR1 (0.45) | TSHRPPARAABCB11CYP1A2CYP3A4 | |
| SCHEMBL7984744 | 0.76 | PPARA (0.53) | TSHRPPARAABCB11CYP1A2CYP3A4 | |
| SCHEMBL21188250 | 0.76 | FBP1 (0.53) | TSHRPPARAABCB11CYP1A2CYP3A4 | |
| SCHEMBL9034864 | 0.76 | PPARA (0.49) | TSHRPPARAABCB11CYP1A2CYP3A4 | |
| SCHEMBL9700152 | 0.76 | FBP1 (0.54) | TSHRPPARAABCB11CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365328-B1 | Pyridine derivatives | ZENECA LTD (GB) | 1996-04-03 | — | — | EP | disclosed |
| US-5053415-A | Antiischemic, antiinflammatory, antiarthritic agents, cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-10-01 | — | — | US | disclosed |
| EP-0365328-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1990-04-25 | — | — | EP | disclosed |