SCHEMBL903540

SCHEMBL903540

Fc1c2n(c3ccc(-c4cnc([C@@H]5CCCN5)[nH]4)cc13)COc1cc(-c3cnc([C@@H]4C[C@@H](F)CN4)[nH]3)ccc1-2

nearest known ligand 0.30

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SSTR3 P32745 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10173681 0.93 SSTR3 (0.34) SSTR3
SCHEMBL17613189 0.78
SCHEMBL19578272 0.76 SCN10A (0.42) SSTR3
SCHEMBL903797 0.75 NR1H4 (0.31) SSTR3
SCHEMBL10219379 0.74 PRCP (0.31)
SCHEMBL19628290 0.74 PRKCZ (0.36)
SCHEMBL10215072 0.72 KCNH2 (0.35) SSTR3
SCHEMBL903698 0.71
SCHEMBL15898229 0.71
SCHEMBL16847261 0.70 MAPK13 (0.37) SSTR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012040923-A1 TETRACYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES MERCK SHARP & DOHME CORP. (US) 2012-04-05 WO disclosed