Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.50 |
| ▸ | HTR1A | P08908 | 5/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035618 | 0.84 | HTR1A (0.58) | DRD3HTR1AHTR7KDM4EALDH1A1 | |
| SCHEMBL3886553 | 0.80 | HTR1A (0.58) | DRD3HTR1AHTR7HRH1HTR2B | |
| SCHEMBL3893010 | 0.80 | HTR1A (0.58) | DRD3HTR1AHTR7HRH1HTR2B | |
| SCHEMBL9035193 | 0.80 | HTR1A (0.47) | DRD3HTR1AHRH1DRD2 | |
| SCHEMBL9036829 | 0.78 | HTR1A (0.47) | HTR1ADRD2 | |
| SCHEMBL9457777 | 0.72 | HTR1A (0.45) | DRD3HTR1AHTR7HRH1HTR2B | |
| Bromide SCHEMBL9457907 | 0.71 | HTR1A (0.44) | DRD3HTR1AHTR7HRH1HTR2B | |
| SCHEMBL20358477 | 0.70 | HTR1A (0.80) | DRD3HTR1AHTR7HRH1HTR2B | |
| SCHEMBL16406297 | 0.69 | HTR1A (0.67) | DRD3HTR1AHTR7KDM4EALDH1A1 | |
| SCHEMBL14028451 | 0.68 | HTR1A (0.79) | DRD3HTR1ADRD2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422134-B1 | 5-HT SELECTIVE AGENTS | ABBOTT LAB (US) | 1996-06-12 | — | — | EP | claimed |
| EP-0422134-B1 | 5-HT SELECTIVE AGENTS | ABBOTT LAB (US) | 1996-06-12 | — | — | EP | disclosed |