Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043016 | 0.87 | MAPT (0.51) | MAPTALDH1A1TDP1L3MBTL1SERPINE1 | |
| SCHEMBL5563843 | 0.82 | SERPINE1 (0.44) | MAPTALDH1A1TDP1L3MBTL1SERPINE1 | |
| SCHEMBL8041727 | 0.82 | MAPT (0.49) | MAPTALDH1A1TDP1L3MBTL1SERPINE1 | |
| SCHEMBL9900549 | 0.81 | MAPT (0.66) | MAPTALDH1A1TDP1L3MBTL1CYP1A2 | |
| SCHEMBL8123521 | 0.80 | SERPINE1 (0.53) | MAPTALDH1A1TDP1L3MBTL1SERPINE1 | |
| SCHEMBL5166296 | 0.79 | MAPT (0.48) | MAPTALDH1A1TDP1L3MBTL1SERPINE1 | |
| SCHEMBL9039303 | 0.78 | ALDH1A1 (0.49) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL9944998 | 0.77 | MAPT (0.47) | MAPTALDH1A1TDP1L3MBTL1CYP1A2 | |
| SCHEMBL8346017 | 0.76 | SERPINE1 (0.53) | MAPTALDH1A1TDP1L3MBTL1SERPINE1 | |
| SCHEMBL6612169 | 0.73 | SERPINE1 (0.48) | MAPTALDH1A1SERPINE1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696288-A1 | QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025469-A1 | QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-11-10 | — | — | WO | disclosed |