Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | CRHBP | P24387 | 1/20 | 0.65 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.65 |
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.63 |
| ▸ | PARP14 | Q460N5 | 7/20 | 0.63 |
| ▸ | PARP1 | P09874 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14277718 | 0.87 | PARP14 (0.69) | HTTMAPTCRHBPCRHR2PARP10 | |
| SCHEMBL8738334 | 0.87 | PARP14 (0.78) | HTTMAPTCRHBPCRHR2PARP10 | |
| SCHEMBL903593 | 0.87 | MAPT (0.85) | HTTMAPTCRHBPCRHR2PARP10 | |
| SCHEMBL257897 | 0.80 | MEN1 (0.64) | HTTMAPTCRHBPCRHR2PARP10 | |
| SCHEMBL903429 | 0.77 | KMT2A (0.85) | HTTMAPTCRHBPCRHR2KMT2A | |
| SCHEMBL10144128 | 0.77 | PARP14 (0.77) | HTTMAPTCRHBPCRHR2PARP10 | |
| SCHEMBL16151037 | 0.76 | MAPT (0.70) | HTTMAPTCRHBPCRHR2PARP10 | |
| SCHEMBL26458618 | 0.75 | LMNA (0.53) | HTTMAPTLMNASMN1; SMN2GAA | |
| SCHEMBL8737735 | 0.74 | MEN1 (0.63) | HTTMAPTLMNASMN1; SMN2GAA | |
| SCHEMBL18753979 | 0.73 | MAPT (0.69) | HTTMAPTLMNASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041987-A1 | SUBSTITUTED N-(2-ARYLAMINO)ARYL SULFONAMIDE-CONTAINING COMBINATIONS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-04-05 | — | — | WO | disclosed |