SCHEMBL9035784

SCHEMBL9035784

COC([O])(c1ccc2ccccc2c1)c1cccc2ccccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.38
PTPRC P08575 1/20 0.38
PTPN1 P18031 2/20 0.37
CYP1A2 P05177 3/20 0.37
CYP2A6 P11509 1/20 0.37
KCNJ11 Q14654 3/20 0.36
MAPK14 Q16539 1/20 0.34
RAB9A P51151 2/20 0.34
KMT2A Q03164 2/20 0.34
NPC1 O15118 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
HPGD P15428 1/20 0.33
CYP2C19 P33261 1/20 0.33
HIF1A Q16665 1/20 0.33
HSD17B10 Q99714 1/20 0.33
ABCC9 O60706 1/20 0.33
ABCC8 Q09428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7587844 0.73 CASR (0.38) MAPTPTPRCPTPN1CYP1A2CYP2A6
SCHEMBL15066593 0.72 PTPRC (0.36) MAPTPTPRCPTPN1CYP1A2CYP2A6
SCHEMBL15066561 0.72 PTPRC (0.36) MAPTPTPRCPTPN1CYP1A2CYP2A6
SCHEMBL12390022 0.71 CYP2A6 (0.48) PTPN1CYP1A2CYP2A6TDP1CYP2D6
SCHEMBL8423690 0.71 ALDH1A1 (0.41) MAPTCYP1A2CYP2A6RAB9ATDP1
SCHEMBL8850104 0.70 ALDH1A1 (0.40) MAPTCYP1A2CYP2A6RAB9ATDP1
SCHEMBL28654871 0.69 ALDH1A1 (0.43) MAPTCYP1A2CYP2A6RAB9ATDP1
SCHEMBL18288054 0.69 CYP2A6 (0.50) PTPN1CYP1A2CYP2A6TDP1HSD17B10
SCHEMBL4196250 0.68 NR1I2 (0.32) CYP1A2KMT2ANPC1HPGDMEN1
SCHEMBL28160585 0.68 PTPRC (0.38) MAPTPTPRCPTPN1CYP1A2CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0749426-A1 QUINOLINE OR QUINAZOLINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS, IN PARTICULAR FOR TREATING ARTHRITIS Takeda Chemical Industries, Ltd. (JP) 1996-12-27 EP disclosed
WO-1995024394-A1 QUINOLINE OR QUINAZOLINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS, IN PARTICULAR FOR TREATING ARTHRITIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-09-14 WO disclosed