Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 7/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | TET3 | O43151 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM5C | P41229 | 1/20 | 0.47 |
| ▸ | ASPH | Q12797 | 1/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.47 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.47 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.47 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.47 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.47 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18519134 | 0.87 | KDR (0.48) | P2RX3KDRMAPTBRAFRAF1 | |
| SCHEMBL257959 | 0.86 | RAF1 (0.50) | P2RX3KDRBRAFRAF1MAPK14 | |
| SCHEMBL4365227 | 0.85 | KDM4E (0.49) | P2RX3KDRKDM4EALDH1A1KDM6B | |
| SCHEMBL22737610 | 0.85 | GCK (0.54) | KDRKDM4EALDH1A1KDM6BTET3 | |
| SCHEMBL6014711 | 0.84 | KDR (0.49) | P2RX3KDRALDH1A1BRAFRAF1 | |
| SCHEMBL4334161 | 0.84 | ALDH1A1 (0.47) | P2RX3KDRKDM4EALDH1A1KDM6B | |
| SCHEMBL2427202 | 0.84 | P2RX3 (0.52) | P2RX3KDRKDM4EALDH1A1KDM6B | |
| Hydrochloric Acid SCHEMBL23067776 | 0.83 | GCK (0.52) | KDRKDM4EALDH1A1KDM6BTET3 | |
| SCHEMBL167964 | 0.83 | KDR (0.68) | P2RX3KDRBRAFRAF1MAPK14 | |
| SCHEMBL23068607 | 0.83 | GRM5 (0.47) | P2RX3KDM4EALDH1A1KDM6BTET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041987-A1 | SUBSTITUTED N-(2-ARYLAMINO)ARYL SULFONAMIDE-CONTAINING COMBINATIONS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-04-05 | — | — | WO | disclosed |