Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL522510 | 0.86 | ALDH1A1 (0.62) | ALDH1A1PRKCAPRKCDKMT2ATDP1 | |
| SCHEMBL18691827 | 0.86 | ALDH1A1 (0.53) | ALDH1A1PRKCAPRKCDKMT2ATDP1 | |
| Ammonia Solution, Strong SCHEMBL27451848 | 0.84 | ALDH1A1 (0.60) | ALDH1A1PRKCAPRKCDKMT2ATDP1 | |
| SCHEMBL28246707 | 0.84 | ALDH1A1 (0.60) | ALDH1A1PRKCAPRKCDKMT2ATDP1 | |
| SCHEMBL24250989 | 0.83 | ALDH1A1 (0.50) | ALDH1A1PRKCAPRKCDKMT2ATDP1 | |
| Carbon Dioxide SCHEMBL28321686 | 0.81 | ALDH1A1 (0.56) | ALDH1A1PRKCAPRKCDKMT2ATDP1 | |
| SCHEMBL1680118 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL10814449 | 0.81 | PRKCA (0.45) | ALDH1A1PRKCAPRKCDKMT2ATDP1 | |
| SCHEMBL11071944 | 0.81 | PRKCA (0.45) | ALDH1A1PRKCAPRKCDKMT2ATDP1 | |
| SCHEMBL27144 | 0.80 | ALDH1A1 (0.68) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294934-B1 | Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids | PFIZER (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5319103-A | Intermediate diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-carboxylic acids | PFIZER INC. (US) | 1994-06-07 | — | — | US | disclosed |
| US-5191077-A | Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids | PFIZER INC. (US) | 1993-03-02 | — | — | US | disclosed |
| EP-0223397-B1 | PROCESS FOR 2-(1-OXO-3-THIOLANYL)-2-PENEM ANTIBIOTICS | PFIZER INC. (US) | 1991-09-04 | — | — | EP | disclosed |
| US-5013729-A | Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids | PFIZER INC. (US) | 1991-05-07 | — | — | US | disclosed |
| US-4870170-A | Process for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics | PFIZER INC. (US) | 1989-09-26 | — | — | US | disclosed |
| US-4794179-A | 2-(1-oxo-3-thiolanyl)-2-penem antibiotics | PFIZER INC. (US) | 1988-12-27 | — | — | US | disclosed |
| EP-0294934-A2 | Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids | PFIZER INC. (US) | 1988-12-14 | — | — | EP | disclosed |
| WO-1988008845-A1 | DIASTEREOMERIC 5R,6S-6-(1R-HYDROXYETHYL)-2-(CIS-1-OXO-3-THIOLANYLTHIO)-2-PENEM-3-CARBOXYLIC ACIDS | PFIZER INC. (US) | 1988-11-17 | — | — | WO | disclosed |
| US-4739047-A | Intermediates for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics | PFIZER INC. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0223397-A2 | Process for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics | PFIZER INC. (US) | 1987-05-27 | — | — | EP | disclosed |