SCHEMBL903654

SCHEMBL903654

Oc1ccc2c(c1)CCc1c-2oc2ccc(O)cc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.51
CYP1A2 P05177 2/20 0.51
CYP2C19 P33261 1/20 0.51
PRKD1 Q15139 3/20 0.51
ALDH1A1 P00352 1/20 0.51
LMNA P02545 1/20 0.51
TP53 P04637 1/20 0.51
HTT P42858 1/20 0.51
CDK5 Q00535 1/20 0.51
CDK5R1 Q15078 1/20 0.51
PRKD2 Q9BZL6 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
ESR1 P03372 2/20 0.41
ESR2 Q92731 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
MAPT P10636 1/20 0.41
CYP2C9 P11712 1/20 0.41
KMT2A Q03164 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12698522 0.91 CYP1A2 (0.56) CYP3A4CYP1A2CYP2C19PRKD1ALDH1A1
SCHEMBL4450756 0.88 KDM4E (0.48) CYP3A4CYP1A2CYP2C19PRKD1ALDH1A1
SCHEMBL13958279 0.81 MIF (0.40) CYP3A4CYP1A2CYP2C19PRKD1ALDH1A1
SCHEMBL12698437 0.78 MAOA (0.51) CYP3A4CYP1A2CYP2C19PRKD1ALDH1A1
SCHEMBL4450658 0.76 ESR1 (0.42) ESR1ESR2MAOAMAOBPRKCI
SCHEMBL3936675 0.74 ESRRB (0.51) CYP3A4CYP1A2CYP2C19PRKD1ALDH1A1
SCHEMBL10401208 0.72 LMNA (0.66) CYP3A4CYP1A2CYP2C19PRKD1ALDH1A1
SCHEMBL4450099 0.72 ESR1 (0.36) ALDH1A1LMNAESR1ESR2KDM4E
SCHEMBL13958284 0.71 ESR1 (0.35) TP53ESR1ESR2MAPTCYP2C9
SCHEMBL784291 0.71 MAOB (0.59) ESR1ESR2MAOAMAOBPRKCI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012041227-A1 TETRACYCLIC HETEROCYCLE COMPOUNDS FOR TREATING HEPATITIS C VIRAL INFECTION MERCK SHARP & DOHME CORP. (US) 2012-04-05 WO disclosed
WO-2012040924-A1 FUSED TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES MERCK SHARP & DOHME CORP. (US) 2012-04-05 WO disclosed