Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7059927 | 0.90 | TP53 (0.76) | TP53KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL8101613 | 0.88 | TP53 (0.78) | TP53ALDH1A1LMNAMAPTGABRA1 | |
| SCHEMBL8027230 | 0.87 | TP53 (0.53) | TP53KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL28972723 | 0.85 | TP53 (0.62) | TP53ALDH1A1LMNAMAPTGABRA1 | |
| SCHEMBL30337088 | 0.85 | TP53 (0.62) | TP53ALDH1A1LMNAMAPTGABRA1 | |
| SCHEMBL6372806 | 0.83 | TP53 (0.66) | TP53KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL8027361 | 0.82 | TP53 (0.75) | TP53LMNAMAPTGABRA1GABRB2 | |
| SCHEMBL6371982 | 0.82 | KDM4E (0.64) | TP53KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL10456699 | 0.81 | TP53 (0.62) | TP53LMNAMAPTGABRA1GABRB2 | |
| SCHEMBL11209054 | 0.81 | TP53 (0.72) | TP53ALDH1A1LMNAMAPTGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0491943-A4 | TETRAHYDROPYRIDOINDOLES AS CHOLECYSTOKININ AND GASTRIN ANTAGONISTS | RORER INT HOLDINGS (US) | 1996-02-14 | — | — | EP | disclosed |
| US-5162336-A | Disorders of gastrointestinal, central nervous and appetite regulatory systems | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-10 | — | — | US | disclosed |
| EP-0491943-A1 | TETRAHYDROPYRIDOINDOLES AS CHOLECYSTOKININ AND GASTRIN ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-07-01 | — | — | EP | disclosed |
| WO-1992000295-A1 | TETRAHYDROPYRIDOINDOLES AS CHOLECYSTOKININ AND GASTRIN ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-01-09 | — | — | WO | disclosed |
| US-4163059-A | Pesticidally active 4,5-dichloro-3-substituted-phenylimino-1,2-dithiolenes | BAYER AKTIENGESELLSCHAFT (DE) | 1979-07-31 | — | — | US | disclosed |