Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 8/20 | 0.52 |
| ▸ | ADRA1B known ✓ | P35368 | 7/20 | 0.52 |
| ▸ | ADRA1A known ✓ | P35348 | 4/20 | 0.52 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035277 | 0.99 | HTR1A (0.52) | HTR1AADRA1BADRA1AADRA1D | |
| SCHEMBL9034851 | 0.85 | HTR1A (0.48) | HTR1AADRA1BADRA1A | |
| SCHEMBL9035193 | 0.83 | HTR1A (0.47) | HTR1AADRA1AADRA1D | |
| SCHEMBL9036829 | 0.81 | HTR1A (0.47) | HTR1AADRA1D | |
| SCHEMBL9034117 | 0.77 | HTR1A (0.58) | HTR1AADRA1BADRA1AADRA1D | |
| Bromide SCHEMBL9457907 | 0.77 | HTR1A (0.44) | HTR1AADRA1BADRA1AADRA1D | |
| SCHEMBL9035223 | 0.76 | HTR1A (0.57) | HTR1AADRA1BADRA1AADRA1D | |
| Hydrochloric Acid SCHEMBL9043516 | 0.76 | HTR1A (0.57) | HTR1AADRA1BADRA1AADRA1D | |
| SCHEMBL9457777 | 0.76 | HTR1A (0.45) | HTR1AADRA1BADRA1AADRA1D | |
| Hydrochloric Acid SCHEMBL9036002 | 0.76 | HTR1A (0.56) | HTR1AADRA1BADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422134-B1 | 5-HT SELECTIVE AGENTS | ABBOTT LAB (US) | 1996-06-12 | — | — | EP | disclosed |