Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.60 |
| ▸ | AGXT | P21549 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 5/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | DRD1 | P21728 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5334857 | 0.89 | LOXL2 (0.56) | LOXL2AGXTHTR2BHTR1ADRD2 | |
| SCHEMBL18255847 | 0.87 | LOXL2 (0.55) | LOXL2AGXTHTR2BHTR1ADRD2 | |
| SCHEMBL4149836 | 0.83 | LOXL2 (0.64) | LOXL2AGXTHTR2BHTR1ADRD2 | |
| SCHEMBL4049122 | 0.80 | LOXL2 (0.60) | LOXL2AGXTHTR2BHTR1ADRD2 | |
| SCHEMBL2249038 | 0.80 | LOXL2 (0.60) | LOXL2AGXTHTR2BHTR1ADRD2 | |
| SCHEMBL297312 | 0.80 | LOXL2 (0.60) | LOXL2AGXTHTR2BHTR1ADRD2 | |
| SCHEMBL6013090 | 0.80 | LOXL2 (0.60) | LOXL2AGXTHTR2BHTR1ADRD2 | |
| SCHEMBL140395 | 0.80 | LOXL2 (0.71) | LOXL2AGXTHTR2BHTR1ADRD2 | |
| SCHEMBL6243293 | 0.80 | LOXL2 (0.66) | LOXL2AGXTHTR2BHTR1ADRD2 | |
| SCHEMBL4048647 | 0.80 | LOXL2 (0.60) | LOXL2AGXTHTR2BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0694033-A1 | INDOLE DERIVATIVES AS 5-HT1A AND/OR 5-HT2 LIGANDS | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1996-01-31 | — | — | EP | disclosed |
| WO-1994024125-A1 | INDOLE DERIVATIVES AS 5-HT1A AND/OR 5-HT2 LIGANDS | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1994-10-27 | — | — | WO | disclosed |
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |