Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.60 |
| ▸ | AGXT | P21549 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 7/20 | 0.46 |
| ▸ | HTR1A | P08908 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287509 | 0.89 | LOXL2 (0.56) | LOXL2AGXTSMN1; SMN2L3MBTL1HTR2B | |
| SCHEMBL29594271 | 0.89 | LOXL2 (0.56) | LOXL2AGXTSMN1; SMN2L3MBTL1HTR2B | |
| Hydrochloric Acid SCHEMBL28989961 | 0.87 | LOXL2 (0.55) | LOXL2AGXTSMN1; SMN2L3MBTL1HTR2B | |
| SCHEMBL252581 | 0.87 | MAPT (0.60) | LOXL2AGXTSMN1; SMN2L3MBTL1HTR2B | |
| SCHEMBL19813189 | 0.85 | MAPT (0.63) | LOXL2AGXTSMN1; SMN2L3MBTL1HTR2B | |
| Hydrochloric Acid SCHEMBL27927458 | 0.85 | LOXL2 (0.53) | LOXL2AGXTSMN1; SMN2L3MBTL1HTR2B | |
| SCHEMBL10000911 | 0.85 | MAPT (0.63) | LOXL2AGXTSMN1; SMN2L3MBTL1HTR2B | |
| SCHEMBL8688187 | 0.85 | MAPT (0.63) | LOXL2AGXTSMN1; SMN2L3MBTL1HTR2B | |
| SCHEMBL11243675 | 0.85 | MAPT (0.63) | LOXL2AGXTSMN1; SMN2L3MBTL1HTR2B | |
| SCHEMBL31499129 | 0.83 | LOXL2 (0.64) | LOXL2AGXTSMN1; SMN2L3MBTL1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112135825-A | Plasma kallikrein inhibitors and uses thereof | 夏尔人类遗传性治疗公司 | 2020-12-25 | — | — | CN | disclosed |
| US-9783490-B2 | Antimicrobial compounds, their synthesis and applications thereof | THE SECRETARY OF STATE FOR HEALTH (GB) | 2017-10-10 | — | — | US | disclosed |
| WO-2013129879-A1 | GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | SK CHEMICALS CO., LTD. (KR) | 2013-09-06 | — | — | WO | disclosed |
| US-7642265-B2 | Benzimidazoles and analogs thereof as antivirals | ISIS PHARMACEUTICALS, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-7408025-B2 | Lipopeptides as antibacterial agents | CUBIST PHARMACEUTICALS, INC. (US) | 2008-08-05 | — | — | US | disclosed |
| US-7390804-B2 | N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-06-24 | — | — | US | disclosed |
| US-7390804-B2 | N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-06-24 | — | — | US | disclosed |
| WO-2007064914-A2 | 5-(ARYLSULFONYL)-PYRAZOLOPIPERIDINES | ELAN PHARMACEUTICALS, INC. (US) | 2007-06-07 | — | — | WO | disclosed |
| US-7115782-B2 | Process for producing aromatic compounds by Friedel-Crafts reaction | SHOWA DENKO K.K. (JP) | 2006-10-03 | — | — | US | disclosed |
| WO-2005118545-A1 | GAS-PHASE OXIDATION OF ALKYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2005-12-15 | — | — | WO | disclosed |
| WO-2005118551-A2 | THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS INC. (US) | 2005-12-15 | — | — | WO | disclosed |
| US-20050222457-A1 | Process for producing aromatic compounds by friedel-crafts reaction | SHOWA DENKO K.K. (JP) | 2005-10-06 | — | — | US | disclosed |
| EP-1511707-A1 | PROCESS FOR PRODUCING AROMATIC COMPOUNDS BY FRIEDEL-CRAFTS REACTION | Showa Denko K.K. (JP) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003101925-A1 | PROCESS FOR PRODUCING AROMATIC COMPOUNDS BY FRIEDEL-CRAFTS REACTION | SHOWA DENKO K. K. (JP) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222457-A1 | Process for producing aromatic compounds by friedel-crafts reaction | PAH, DDC, TYR | LOXL2 2293/4885AGXT 295/4885SMN1; SMN2 4141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.