Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 8/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 8/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 8/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 8/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9054998 | 0.82 | GRIN2D (0.52) | HTTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL19782954 | 0.82 | RPS6KA3 (0.39) | HTTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8873815 | 0.79 | CA12 (0.45) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL29650339 | 0.74 | PSMB8 (0.45) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL2359356 | 0.74 | PSMB8 (0.45) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL8692333 | 0.73 | GRIN2D (0.50) | HTTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9228663 | 0.70 | MAPKAPK2 (0.50) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL30637065 | 0.70 | MAPKAPK2 (0.50) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL16671449 | 0.70 | MAPKAPK2 (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL9039429 | 0.70 | ALDH1A1 (0.43) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518530-B1 | Improvements in or relating to excitatory amino acid receptor antagonists | LILLY CO ELI (US) | 1996-10-09 | — | — | EP | disclosed |
| EP-0520024-B1 | QUINOXALINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1996-06-19 | — | — | EP | disclosed |
| US-5196421-A | Treatment of neurological disorders | ELI LILLY AND COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0520024-A1 | QUINOXALINE COMPOUNDS AND THEIR PREPARATION AND USE. | NOVO NORDISK AS (DK) | 1992-12-30 | — | — | EP | disclosed |
| EP-0518530-A2 | Improvements in or relating to excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1992-12-16 | — | — | EP | disclosed |
| US-5166155-A | Neurological or psychiatric diseases | NOVO NORDISK A/S (DK) | 1992-11-24 | — | — | US | disclosed |
| US-5153196-A | Administering for reduction of neurotransmission in nervous system disorders | ELI LILLY AND COMPANY (US) | 1992-10-06 | — | — | US | disclosed |
| WO-1991013878-A1 | QUINOXALINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-09-19 | — | — | WO | disclosed |