Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7805133 | 0.83 | DRD2 (0.55) | HTR2CDRD2HTR2ASIGMAR1DRD3 | |
| SCHEMBL8307276 | 0.75 | — | — | |
| SCHEMBL7805201 | 0.75 | HTR2C (0.43) | HTR2CDRD2HTR2ASIGMAR1DRD3 | |
| SCHEMBL7812220 | 0.73 | DRD2 (0.64) | HTR2CDRD2HTR2ASIGMAR1DRD3 | |
| SCHEMBL7822917 | 0.71 | HTR2C (0.41) | HTR2CADRA2AADRA2CHTR1AADRA1A | |
| SCHEMBL8307272 | 0.70 | DRD2 (0.37) | HTR2CDRD2HTR2ASIGMAR1DRD3 | |
| SCHEMBL8306513 | 0.70 | DRD2 (0.37) | HTR2CDRD2HTR2ASIGMAR1DRD3 | |
| SCHEMBL7811838 | 0.69 | HTR2C (0.48) | HTR2C | |
| SCHEMBL7818312 | 0.69 | GAA (0.35) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL7805273 | 0.69 | HTR3A (0.49) | HTR2CDRD2SIGMAR1DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745598-A1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |