Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.49 |
| ▸ | PDE4A | P27815 | 4/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | RGS12 | O14924 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038148 | 0.80 | AURKA (0.49) | ADORA2AAURKAADORA3ADORA2BMEN1 | |
| SCHEMBL9038552 | 0.78 | PDE4B (0.45) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9038020 | 0.77 | PDE4A (0.52) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6644063 | 0.73 | ADORA2A (0.49) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1713392 | 0.73 | FEN1 (0.60) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9039440 | 0.71 | ADORA2A (0.51) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12400696 | 0.69 | DAO (0.58) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29795662 | 0.69 | DAO (0.58) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9039524 | 0.68 | ADORA3 (0.50) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9040140 | 0.68 | ADORA2A (0.51) | ADORA2APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696590-A1 | Pyrido[2,3-d]pyrimidine derivatives, their preparation and their use as anti-asthma agents | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-02-14 | — | — | EP | disclosed |