Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9040350 | 0.88 | AKR1B1 (0.57) | AKR1B1 | |
| SCHEMBL9039730 | 0.83 | KDM1A (0.51) | AKR1B1 | |
| SCHEMBL9041006 | 0.80 | AKR1B1 (0.49) | AKR1B1SIGMAR1 | |
| SCHEMBL8749278 | 0.78 | TSHR (0.54) | AKR1B1 | |
| SCHEMBL9039535 | 0.76 | AKR1B1 (0.46) | AKR1B1SIGMAR1 | |
| SCHEMBL9038140 | 0.74 | OPRM1 (0.46) | AKR1B1DRD2DRD3 | |
| SCHEMBL9042847 | 0.72 | AKR1B1 (0.41) | AKR1B1 | |
| SCHEMBL9198597 | 0.70 | AKR1B1 (0.50) | AKR1B1 | |
| SCHEMBL15053396 | 0.69 | SIGMAR1 (0.51) | SIGMAR1DRD2DRD1DRD4DRD5 | |
| SCHEMBL9284139 | 0.67 | KDM1A (0.44) | AKR1B1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441598-B1 | Spiroisoindole compounds | ZENECA INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5098925-A | Neurological disorders in mammals | ICI AMERICAS INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0441598-A2 | Spiroisoindole compounds | ZENECA INC. (US) | 1991-08-14 | — | — | EP | disclosed |