Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 9/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30035692 | 0.75 | GRIN2D (0.44) | EGFR | |
| SCHEMBL18719389 | 0.69 | EGFR (0.40) | EGFR | |
| SCHEMBL7687471 | 0.69 | KMO (0.45) | PDE3BPDE3AEGFR | |
| SCHEMBL8874014 | 0.69 | EGFR (0.58) | EGFR | |
| SCHEMBL338446 | 0.69 | PDE3B (0.49) | PDE3BPDE3ACMA1MKNK1 | |
| SCHEMBL6017066 | 0.68 | KDM4E (0.44) | EGFR | |
| SCHEMBL26423685 | 0.68 | EGFR (0.39) | EGFR | |
| SCHEMBL4430364 | 0.68 | PDE3B (0.41) | PDE3BPDE3ACMA1PGR | |
| SCHEMBL4427818 | 0.68 | CMA1 (0.38) | PDE3BPDE3ACMA1MKNK1PGR | |
| SCHEMBL28673518 | 0.67 | PDE3B (0.36) | PDE3BPDE3ACMA1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741711-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995019970-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1995-07-27 | — | — | WO | disclosed |