Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.40 |
| ▸ | ME2 | P23368 | 2/20 | 0.40 |
| ▸ | ME1 | P48163 | 2/20 | 0.40 |
| ▸ | ME3 | Q16798 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 6/20 | 0.36 |
| ▸ | PPARA | Q07869 | 6/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9039853 | 0.88 | MAPT (0.55) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL9665897 | 0.79 | MAPT (0.65) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL14764336 | 0.78 | MAPT (0.65) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL7834009 | 0.78 | MAPT (0.64) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL8504055 | 0.77 | MAPT (0.57) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL7458461 | 0.77 | MAPT (0.56) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL9665027 | 0.77 | MAPT (0.62) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL9666082 | 0.76 | MAPT (0.62) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL20639883 | 0.76 | PPARD (0.41) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL7834002 | 0.75 | MAPT (0.61) | MAPTKDM4EALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402989-B1 | Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones | JANSSEN PHARMACEUTICA NV (BE) | 1996-04-03 | — | — | EP | disclosed |
| US-5075309-A | For prevention and treatment of fungal diseases in mammals | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-24 | — | — | US | disclosed |