Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.68 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.68 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.68 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.68 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.68 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.68 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.68 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.68 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.68 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.68 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9037767 | 0.81 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL9037104 | 0.77 | GRIA1 (0.62) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL3493681 | 0.75 | GRIA1 (0.68) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL9038869 | 0.75 | POLB (0.58) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL1599006 | 0.74 | POLB (1.00) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL30273081 | 0.74 | POLB (1.00) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL123451 | 0.64 | KDM4E (0.58) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7983698 | 0.63 | TP53 (0.35) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL16824184 | 0.63 | KDM4E (0.46) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL31026839 | 0.63 | TP53 (0.35) | GRIA1GRIA2GRIA3GRIA4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518530-B1 | Improvements in or relating to excitatory amino acid receptor antagonists | LILLY CO ELI (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5196421-A | Treatment of neurological disorders | ELI LILLY AND COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| US-5153196-A | Administering for reduction of neurotransmission in nervous system disorders | ELI LILLY AND COMPANY (US) | 1992-10-06 | — | — | US | disclosed |