Sugi Predict

Sugi Predict / Compounds / SCHEMBL7983698

SCHEMBL7983698

SCHEMBL7983698

O=c1[nH]c2cc(F)c(Br)cc2n2cncc12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 1/20 0.35
▸ GRIN2D O15399 2/20 0.34
▸ GRIN3B O60391 2/20 0.34
▸ GRIA1 P42261 2/20 0.34
▸ GRIA2 P42262 2/20 0.34
▸ GRIA3 P42263 2/20 0.34
▸ GRIA4 P48058 2/20 0.34
▸ GRIN1 Q05586 2/20 0.34
▸ GRIN2A Q12879 2/20 0.34
▸ GRIN2B Q13224 2/20 0.34
▸ GRIN2C Q14957 2/20 0.34
▸ GRIN3A Q8TCU5 2/20 0.34
▸ DAO P14920 1/20 0.33
▸ EGLN1 Q9GZT9 1/20 0.33
▸ GABRA5 P31644 2/20 0.31
▸ LYN P07948 1/20 0.31
▸ BTK Q06187 1/20 0.31
▸ CHEK1 O14757 1/20 0.30
▸ CHEK2 O96017 1/20 0.30
▸ CDK1 P06493 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31026839 1.00 TP53 (0.35) TP53GRIN2DGRIN3BGRIA1GRIA2
SCHEMBL29235228 0.83 GRIA1 (0.46) TP53GRIN2DGRIN3BGRIA1GRIA2
SCHEMBL29235288 0.83 GRIN2D (0.37) TP53GRIN2DGRIN3BGRIA1GRIA2
SCHEMBL31026868 0.82 GRIA1 (0.36) TP53GRIN2DGRIN3BGRIA1GRIA2
SCHEMBL31353079 0.80 GRIN2D (0.36) TP53GRIN2DGRIN3BGRIA1GRIA2
SCHEMBL31137380 0.80 GRIA1 (0.34) TP53GRIN2DGRIN3BGRIA1GRIA2
SCHEMBL7982902 0.80 GRIN2D (0.54) TP53GRIN2DGRIN3BGRIA1GRIA2
SCHEMBL29235466 0.77 TP53 (0.46) TP53GABRA5BTKCHEK1GSK3B
SCHEMBL31353069 0.77 TP53 (0.60) TP53GABRA5BTKCHEK1CHEK2
SCHEMBL7980241 0.77 DAO (0.46) DAOGABRA5GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12448388-B2 PRMT5 inhibitors and uses thereof GILEAD SCIENCES, INC. (US) 2025-10-21 — — US disclosed
US-20240376110-A1 PRMT5 INHIBITORS AND USES THEREOF GILEAD SCIENCES, INC. 2024-11-14 — — US disclosed
WO-2024220917-A1 PRMT5 INHIBITORS AND USES THEREOF GILEAD SCIENCES, INC. (US) 2024-10-24 — — WO disclosed
CN-118221682-A Amide compound, pharmaceutical composition containing same, preparation method and application thereof 四川科伦博泰生物医药股份有限公司 2024-06-21 — — CN disclosed
US-6235740-B1 AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS BRISTOL-MYERS SQUIBB CO. 2001-05-22 — — US disclosed
WO-1999009845-A1 IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-03-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240376110-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT5, PRMT1, PRMT9 TP53 371/4885GRIN2D 3738/4885GRIN3B 3069/4885
US-12448388-B2 PRMT5 inhibitors and uses thereof PRMT5, PRMT1, PRMT9 TP53 371/4885GRIN2D 3738/4885GRIN3B 3069/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.