Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.54 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.54 |
| ▸ | FYN | P06241 | 3/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | MELK | Q14680 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1642998 | 0.84 | ENPP2 (0.52) | MAP4K4MINK1FYNTNIKENPP2 | |
| SCHEMBL27635242 | 0.79 | KCNH2 (0.48) | MAP4K4MINK1FYNTNIKPTGS2 | |
| SCHEMBL387688 | 0.79 | ENPP2 (0.47) | MAP4K4MINK1FYNTNIKENPP2 | |
| SCHEMBL4488979 | 0.78 | MAP4K4 (0.54) | MAP4K4MINK1FYNTNIKKCNH2 | |
| SCHEMBL3889610 | 0.78 | PTGS2 (0.53) | MAP4K4MINK1FYNTNIKPTGS2 | |
| SCHEMBL8423018 | 0.77 | PTGS2 (0.51) | MAP4K4MINK1FYNTNIKPTGS2 | |
| SCHEMBL28303516 | 0.77 | PTGS2 (0.51) | MAP4K4MINK1FYNTNIKENPP2 | |
| SCHEMBL30619390 | 0.77 | MEN1 (0.44) | MAP4K4 | |
| SCHEMBL10300269 | 0.77 | PTGS2 (0.62) | ENPP2PTGS2PTGS1 | |
| SCHEMBL7677302 | 0.77 | PTGS2 (0.62) | ENPP2PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |