Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9039193 | 1.00 | USP2 (0.53) | USP2HPGDNPSR1ALDH1A1KDM4E | |
| SCHEMBL13560835 | 0.75 | CTSL (0.55) | NPSR1ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL6644355 | 0.72 | USP2 (0.78) | USP2HPGDNPSR1KDM4EHTT | |
| SCHEMBL5455999 | 0.69 | USP2 (0.92) | USP2HPGDNPSR1MAPTHTT | |
| SCHEMBL3578599 | 0.69 | USP2 (0.92) | USP2HPGDNPSR1MAPTHTT | |
| SCHEMBL3578601 | 0.69 | USP2 (0.92) | USP2HPGDNPSR1MAPTHTT | |
| SCHEMBL7971943 | 0.68 | HPGD (1.00) | USP2HPGDNPSR1ALDH1A1KDM4E | |
| SCHEMBL31033168 | 0.68 | HPGD (1.00) | USP2HPGDNPSR1ALDH1A1KDM4E | |
| SCHEMBL9039217 | 0.68 | HPGD (0.45) | USP2HPGDNPSR1GAAMAPT | |
| SCHEMBL9039222 | 0.68 | HPGD (0.45) | USP2HPGDNPSR1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0465254-B1 | Fused thiophene compounds and uses thereof | YOSHITOMI PHARMACEUTICAL (JP) | 1996-11-13 | — | — | EP | disclosed |
| US-5141930-A | Antianxietic drug, antipsychotics and cardiotonic agents | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| EP-0465254-A1 | Fused thiophene compounds and uses thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1992-01-08 | — | — | EP | disclosed |
| EP-0304222-A2 | Amino-2-hydroxypropyloximino-heterocycle beta blockers | MERCK & CO. INC. (US) | 1989-02-22 | — | — | EP | disclosed |
| US-4803286-A | GLAUCOMA HYPERTENSION, ANGINA PECTORIS AND ARRYTHMIA TREATMENT | MERCK & CO., INC. (US) | 1989-02-07 | — | — | US | disclosed |