SCHEMBL9039455

SCHEMBL9039455

COc1cc(OC)c(C)c(C(=O)O)c1C

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.55
CA12 O43570 3/20 0.54
CA1 P00915 3/20 0.54
CA2 P00918 3/20 0.54
CA7 P43166 3/20 0.54
CA9 Q16790 3/20 0.54
CA14 Q9ULX7 3/20 0.54
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
MAPT P10636 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
HPGD P15428 2/20 0.47
POLB P06746 1/20 0.47
GFER P55789 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
CA4 P22748 2/20 0.47
CA6 P23280 2/20 0.47
CA3 P07451 1/20 0.47
PKM P14618 1/20 0.47
CA5A P35218 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5226973 0.88 LCK (0.52) CYP3A4CA12CA1CA2CA7
SCHEMBL13149136 0.87 CYP3A4 (0.56) CYP3A4CA12CA1CA2CA7
SCHEMBL1822694 0.86 CYP3A4 (0.47) CYP3A4CA12CA1CA2CA7
SCHEMBL14511729 0.82 CYP3A4 (0.56) CYP3A4CA12CA1CA2CA7
SCHEMBL31638876 0.81 CYP3A4 (0.63) CYP3A4CA12CA1CA2CA7
SCHEMBL6828042 0.81 MEN1 (0.48) CYP3A4CA12CA1CA2CA7
SCHEMBL31022830 0.80 CA12 (0.63) CYP3A4CA12CA1CA2CA7
SCHEMBL11906262 0.80 CA12 (0.63) CYP3A4CA12CA1CA2CA7
SCHEMBL12586587 0.79 CYP3A4 (0.49) CYP3A4CA12CA1CA2CA7
SCHEMBL4155491 0.78 CYP3A4 (0.47) CYP3A4CA12CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0535192-B1 NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME HOFFMANN LA ROCHE (CH) 1996-06-19 EP disclosed
US-5486466-A ENZYME INHIBITORS HOFFMANN-LA ROCHE INC. (US) 1996-01-23 US disclosed
US-5399741-A DNA gyrase inhibitors, process for their manufacture and pharmaceutical preparations containing same HOFFMANN-LA ROCHE INC. (US) 1995-03-21 US disclosed
US-5294609-A Microbiocides HOFFMANN-LAROCHE INC. (US) 1994-03-15 US disclosed
EP-0535192-A1 NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME. HOFFMANN LA ROCHE (CH) 1993-04-07 EP disclosed
WO-1992018490-A1 NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME F. HOFFMANN-LA ROCHE AG (CH) 1992-10-29 WO disclosed